The new title, to be called the Docklands & East London Advertiser, will launch on 10 November with increased pagination.
Bosses say research showed that a single title serving the borough was “the best way to serve the community.”
Archant London editorial director Bob Crawley said: “The new Docklands & East London Advertiser will build on the tradition of the Advertiser and the innovation of The Docklands to provide an insightful read for the residents of Tower Hamlets.
“From an employment and shopping destination perspective Canary Wharf has become a key part of the every day life for Tower Hamlets’ residents.
“Research conducted by the Canary Wharf group shows the estate is now the largest centre of employment for local residents as well as having close to 1m visitors a week to the shopping centre.
“This indicates one title serving the borough is the most effective way to serve the community.”