Natalie left her home in Lower Gornal, Dudley, to go to a shop in September 2003, leaving behind her baby son, then aged 11 weeks.
She has not been seen since.
The E&S’s video, narrated by chief reporter Alex Ross, comes after police confirmed last month the disappearance was being treated as a murder investigation after new information came in.
“Credible” new information led police to exhume graves at a cemetery near her home, but the case has gone cold again after the search yielded no clues.
Express & Star editor Keith Harrison said: “This case involving the disappearance of a young girl is one of the most disturbing cases in recent decades and we share the family’s distress over what happened to her.
“Someone knows what happened and, like the family, the Express & Star will not rest until we get answers over her disappearance.
“I’d urge anyone with information to call police on 101 or Crimestoppers on 0800 555 111.”