Two central production hubs covering seven daily newspapers in the East Midlands and North-East are set to be created by Northcliffe Media.
Up to 50 sub-editing jobs could be under threat if plans for the two "production centres of excellence" in Nottingham and Hull go ahead.
Under the plans, announced to staff at 2pm this afternoon, the Leicester Mercury, Derby Evening Telegraph and Nottingham Evening Post would all be subbed from Nottingham.
Meanwhile, the Hull centre would be responsible for production of the Lincolnshire Echo, Grimsby Telegraph and Scunthorpe Telegraph as well as the Hull Daily Mail.
In a separate development, sister company Harmsworth Press is also proposing the closure of its printing plant in Leicester which currently prints the Mercury.
The company has begun a formal 30-day period of consultation over the possible closure which would affect up to 66 press staff.
A statement issued by Northcliffe this afternoon said the plans were designed to meet "the rapidly changing needs of the industry."
"The proposed changes involve a regional approach to editorial production. Editors, however, will be fully responsible for their titles to preserve the local identity of the newspapers and websites," it said.
The company said that editors were entering into a consultation process with staff in editorial production roles, but stressed that no firm decisions had been taken.
According to the statement, around 50 positions could be affected if the editorial production proposals go ahead.
On the Leicester print closure, the company said it was "not unusual for regional daily newspapers to be printed at locations away from the publishing business."
It said that if the closure plans go ahead, printing of the Mercury and other newspapers will be switched to one of the remaining Northcliffe presses where there is capacity for more titles to be accommodated.
Northcliffe had previously announced plans to centralise production of its Staffordshire titles at The Sentinel offices in Stoke, and a number of its West Country weekly titles at its Bristol centre.
Johnston Press is also planning a centralised subbing operation for its titles in Lincolnshire, Northamptonshire, Buckinghamshire and parts of East Anglia.
The National Union of Journalists this afternoon hit out at the Northcliffe plans, accusing the company of "a total lack of committment to local journalism."
Northern regional organiser Chris Morley said: "Local knowledge will go out of the window."